Package: PK 1.3-6

PK: Basic Non-Compartmental Pharmacokinetics

Estimation of pharmacokinetic parameters using non-compartmental theory.

Authors:Thomas Jaki <[email protected]> and Martin J. Wolfsegger <[email protected]>

# Install 'PK' in R:

install.packages('PK', repos = c('https://tjaki.r-universe.dev', 'https://cloud.r-project.org'))

Datasets:

CPI975 - Plasma levels of CPI975 in rats following a single oral dose
Glucose - Baseline adjusted glucose levels following alcohol ingestion
Rats - Plasma levels in female rats following a single oral dose
Rep.tox - Plasma levels in rats following daily intravenous administration in a repeated dose toxicity study

On CRAN:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

Last updated 1 years agofrom:59639ca702. Checks:OK: 7. Indexed: yes.

Dependencies:

Help page	Topics
Different generic functions for class PK.	plot.PK print.PK summary.PK
Estimation of confidence intervals for the area under the concentration versus time curve in complete and incomplete data designs	auc auc.batch auc.ssd
Confidence intervals for the area under the concentration versus time curve in complete data designs	auc.complete
Two-phase half-life estimation by biexponential model	biexp
Function to extract confidence interval(s)	ci
Plasma levels of CPI975 in rats following a single oral dose	CPI975
Bioequivalence between AUCs	eqv eqv.batch eqv.complete eqv.ssd
Function to extract point estimate(s)	estimator
Baseline adjusted glucose levels following alcohol ingestion	Glucose
Two-phase half-life estimation by linear fitting	lee
Estimation of various PK parameters	nca nca.batch nca.complete nca.ssd
Shows changes and news	PKNews
Plot regression lines used for half-life estimation	plot.halflife
Plasma levels in female rats following a single oral dose	Rats
Plasma levels in rats following daily intravenous administration in a repeated dose toxicity study	Rep.tox
Function for hypothesis testing for objects of class PK	print.PKtest summary.PKtest test