NEWS

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PK 1.3-6 (2023-09-12)

• Internal changes to comply with CRAN rules

PK 1.3-5 (2020-04-02)

• Internal changes to ensure compatability with newer versions of R

PK 1.3-4 (2018-02-26)

• Fixed a bug in auc.ssd, auc.batch, eqv.batch

PK 1.3-3 (2016-01-06)

• Removal of depreciated function call

PK 1.3-2 (2013-08-10)

• A bug during start-up is corrected

PK 1.3-1 (2013-01-10)

• depreciated functions as.real replaced by as.double

PK 1.3-0 (2012-07-25)

• Flexible batch designs (Jaki & Wolfsegger, Statistics in Medicine 2012) implemented. These designs allow the same timepoints to be used in different batches. Functions updated: auc.batch Help files updated: auc.batch, eqv.batch
• Methods to compute PK parameters such as Clearance in flexible batch designs have been added in functions nca and nca.batch
• Help for nca updated
• Help for eqv.ssd, eqv.batch and eqv.complete has been merged with eqv

PK 1.2-5 (2011-11-17)

• Code in biexp and lee updated
• Several examples in help files biexp and lee added

PK 1.2-4 (2011-05-18)

• The help file for the function nca has been corrected
• Citation information updated

PK 1.2-3 (2010-10-08)

• A bug in an internal function to handle the data argument in batch designs fixed
• Citation information updated
• A bug in the nca.complete function fixed
• A bug in the summary function fixed

PK 1.2-2 (2010-04-22)

• A repeated dose toxicity dataset included
• Help on nca function expanded
• A bug in the print function fixed
• auc.complete updated to handle individual AUCs
• Additional example in help for auc.complete included
• Function nca.complete included

PK 1.2-1 (2010-02-08)

• Default option for method lee changed to ols
• Functionality to create plots by group included
• Some formating changes in the print/summary functions
• Bug in print.PKtest fixed
• Bug in test fixed

PK 1.2-0 (2010-01-20)

• Multiple datasets included
• Bug in auc.batch fixed
• Functions can now be called using data in FDA SEND format - http://www.cdisc.org/send
• Functions est, ci and test have been included to obtain point estimates, confidence intervals and hypothesis tests
• Functions auc, eqv, nca have been aligned
• Methods to test for bioequivalence in batch designs for independent and dependent aucs have been added in functions eqv and eqv.batch
• Methods to compute PK parameters such as MRT and Clearance in serial sampling designs have been added in functions nca and nca.ssd
• Multiple references added and updated