Changes in version 1.3-6 (2023-09-12)                  

    o   Internal changes to comply with CRAN rules

                 Changes in version 1.3-5 (2020-04-02)                  

    o   Internal changes to ensure compatability with newer versions of R

                 Changes in version 1.3-4 (2018-02-26)                  

    o   Fixed a bug in auc.ssd, auc.batch, eqv.batch

                 Changes in version 1.3-3 (2016-01-06)                  

    o   Removal of depreciated function call

                 Changes in version 1.3-2 (2013-08-10)                  

    o   A bug during start-up is corrected

                 Changes in version 1.3-1 (2013-01-10)                  

    o   depreciated functions as.real replaced by as.double

                 Changes in version 1.3-0 (2012-07-25)                  

    o   Flexible batch designs (Jaki & Wolfsegger, Statistics in Medicine 2012)
	implemented. These designs allow the same timepoints to be used in 
	different batches. 
	Functions updated:  auc.batch
	Help files updated: auc.batch, eqv.batch

    o   Methods to compute PK parameters such as Clearance in flexible
	batch designs have been added in functions nca and nca.batch

    o   Help for nca updated

    o   Help for eqv.ssd, eqv.batch and eqv.complete has been merged with eqv

                 Changes in version 1.2-5 (2011-11-17)                  

    o   Code in biexp and lee updated

    o   Several examples in help files biexp and lee added 

                 Changes in version 1.2-4 (2011-05-18)                  

    o   The help file for the function nca has been corrected

    o   Citation information updated

                 Changes in version 1.2-3 (2010-10-08)                  

    o   A bug in an internal function to handle the data argument in batch 
	designs fixed

    o   Citation information updated

    o   A bug in the nca.complete function fixed

    o   A bug in the summary function fixed

                 Changes in version 1.2-2 (2010-04-22)                  

    o   A repeated dose toxicity dataset included

    o   Help on nca function expanded

    o   A bug in the print function fixed

    o   auc.complete updated to handle individual AUCs

    o   Additional example in help for auc.complete included

    o   Function nca.complete included

                 Changes in version 1.2-1 (2010-02-08)                  

    o   Default option for method lee changed to ols

    o   Functionality to create plots by group included

    o   Some formating changes in the print/summary functions

    o   Bug in print.PKtest fixed

    o   Bug in test fixed

                 Changes in version 1.2-0 (2010-01-20)                  

    o   Multiple datasets included

    o   Bug in auc.batch fixed

    o   Functions can now be called using data in FDA SEND format - http://www.cdisc.org/send

    o   Functions est, ci and test have been included to obtain point estimates, confidence intervals and hypothesis tests

    o   Functions auc, eqv, nca have been aligned

    o   Methods to test for bioequivalence in batch designs for independent and dependent aucs have been added in functions eqv and eqv.batch

    o   Methods to compute PK parameters such as MRT and Clearance in serial sampling designs have been added in functions nca and nca.ssd

    o   Multiple references added and updated